E. Leclerc et al. S100-RAGE interaction and influence on cell survival S100B AND S100A6 DIFFERENTIALLY MODULATE CELL SURVIVAL BY INTERACTING WITH DISTINCT RAGE IMMUNOGLOBULIN DOMAINS
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چکیده
1 Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland 2 Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA 3 Department of Biology, University of Konstanz, Universitätsstrasse 10, Postfach M665, 78457 Konstanz, Germany Running title: S100-RAGE interaction and influence on cell survival
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RAGE and S100 protein transcription levels are highly variable in human melanoma tumors and cells.
The Receptor for Advanced Glycation Endproducts (RAGE) has been suggested to play an important role in melanoma. Animal studies with anti-RAGE antibodies have shown that RAGE blockade leads to reduced melanoma tumor growth and metastasis formation. RAGE is a multiligand receptor and among its ligands are the Ca-binding S100 proteins. Certain S100 proteins are differentially expressed in melanom...
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